Publicaciones

Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice. Gomez-Gutierrez R, Ghosh U, Yau WM, Gamez N, Katherine Do, Kramm C, Shirani H, Vegas-Gomez L, Schulz J, Moreno-Gonzalez I, Gutierrez A, Nilsson PR, Tycko R, Soto C, Morales R. EMBO Reports (2023). e57003 10.15252/embr.202357003

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus. Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, A Gutierrez, Vitorica J. Acta Neuropathologica Communications (2023) 11(1):31. doi: 10.1186/s40478-023-01530-z

A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer’s disease. Quan L, Moreno-Gonzalez I*, Xie Z, Gamez N, Vegas-Gomez L, Song Q, Gu J, Lin W, Gomez-Gutierrez R, Wu T*. Alzheimer’s Dement. (2023) 19:2 456– 466. https://doi.org/10.1002/alz.12673. *Senior author. Featured article.

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valderrama JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. International Journal of Molecular Sciences (2022) 12;23(10):5404. doi: 10.3390/ijms23105404.

Preventive and therapeutic reduction of amyloid deposition and behavioral impairments in a mouse model of Alzheimer’s disease by whole blood exchange. Urayama A, Moreno-Gonzalez I, Morales-Scheihing D, Kharat V, Pritzkow S, Soto C. Molecular psychiatry (2022) 27(10):4285-4296.doi: 10.1038/s41380-022-01679-4

Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease. Salvadores N, Moreno-Gonzalez I, Gamez N, Quiroz G, Vegas-Gomez L, Escandon M, Jimenez S, Vitorica J, Gutierrez A, Soto C, Court FA. Acta Neuropathologica Communications (2022) 10:31. doi: 10.1186/s40478-022-01332-9

Aged cattle brain displays Alzheimer’s disease–like pathology and is able to accelerate Alzheimer’s pathology in transgenic animal models. Moreno-Gonzalez I*, Edwards III G, Morales R, Duran-Aniotz C, Marquez M, Pumarola M, Soto C*. Frontiers in Aging Neuroscience (2022) 13:815361. doi: 10.3389/fnagi.2021.815361. *Co-corresponding author

G-quadruplexes stabilization upregulates CCN1 and accelerates aging in cultured cerebral endothelial cells. Noh B, Blasco-Conesa MP, Lai YJ, Ganesh BP, Urayama A, Moreno-Gonzalez I, Marrelli S, McCullough LD, Moruno-Manchon JF. Frontiers in Aging (2022) 2:797562. doi.org/10.3389/fragi.2021.797562.

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis. Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, Jimenez S, Sanchez-Mico MV, Trujillo-Estrada L, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Front Neurosci. 2021 Nov 4;15:752594. doi: 10.3389/fnins.2021.752594. eCollection 2021.PMID: 3480358

Age-related immune alterations and cerebrovascular inflammation.Finger CE, Moreno-Gonzalez I, Gutierrez A, Moruno-Manchon JF, McCullough LD. Mol Psychiatry. 2021 Oct 28. doi: 10.1038/s41380-021-01361-1. Online ahead of print.PMID: 34711943

Inflammatory Cascade in Alzheimer’s Disease Pathogenesis: A Review of Experimental Findings. de Oliveira J, Kucharska E, Garcez ML, Rodrigues MS, Quevedo J, Moreno-Gonzalez I, Budni J. Cells. 2021 Sep 28;10(10):2581. doi: 10.3390/cells10102581.PMID: 34685563

Longitudinal Assessment of Tau-Associated Pathology by ¹⁸F-THK5351 PET Imaging: A Histological, Biochemical, and Behavioral Study. Moreno-Gonzalez I, Edwards GA 3rd, Hasan O, Gamez N, Schulz JE, Fernandez-Valenzuela JJ, Gutierrez A, Soto C, Schulz PE. Diagnostics. 2021 Oct 12;11(10):1874. doi: 10.3390/diagnostics11101874.PMID: 34679572

Transmission of cerebral amyloid pathology by peripheral administration of misfolded Aβ aggregates. Morales R, Bravo-Alegria J, Moreno-Gonzalez I, Duran-Aniotz C, Gamez N, Edwards Iii G, Soto C.Mol Psychiatry. 2021 May 17:10.1038/s41380-021-01150-w. doi: 10.1038/s41380-021-01150-w. Online ahead of print.PMID: 34002023

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology.
Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM.Nat Commun. 2021 Apr 23;12(1):2421. doi: 10.1038/s41467-021-22624-z.PMID: 33893290

Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability. Duran-Aniotz C, Moreno-Gonzalez I, Gamez N, Perez-Urrutia N, Vegas-Gomez L, Soto C, Morales R.Acta Neuropathol Commun. 2021 Mar 30;9(1):56. doi: 10.1186/s40478-021-01155-0.PMID: 33785065

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches. Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D.Neuroscientist. 2021 Mar 26:10738584211001753. doi: 10.1177/10738584211001753. PMID: 33769131

Enhancing microtubule stabilization rescue cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model. Fernandez-Valenzuela JJ, Sanchez-Varo R, Sanchez-Mejias E, Gomez-Arboledas A, Moreno-Gonzalez I, Vizuete M, Vitorica J, Gutierrez A. Scientific Reports (2020) 10:14776. doi: 10.1038/s41598-020-71767-4

Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau. Wu J, Carlock C, Shim J, Moreno-Gonzalez I, Glass II W, Ross A, Barichello T, Quevedo J, Lou Y. Molecular psychiatry (2020), 10.1038/s41380-020-00992-0. doi: 10.1038/s41380-020-00992-0

Editorial: Risk Factors for Alzheimer’s Disease. Moreno-Gonzalez I, Morales R, Blagietto-Vargas D, Sanchez-Varo R. Front Aging Neurosci. 2020 May 7;12:124. doi:10.3389/fnagi.2020.00124. eCollection 2020 PMID: 32457597

Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology. . Edwards Iii G, Gamez N, Armijo E, Kramm C, Morales R, Taylor-Presse K, Schulz PE, Soto C, Moreno-Gonzalez I. Cells. 2019 Oct 30;8(11):1359. doi: 10.3390/cells8111359. PMID: 31671704

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. . Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez N, Soto P, Soto C, Hetz C, Court FA. Cell Death Differ. 2020 Apr;27(4):1169-1185. doi: 10.1038/s41418-019-0408-4. Epub 2019 Oct 7. PMID: 31591470

Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases.. Cuanalo-Contreras K, Moreno-Gonzalez I.
Int J Mol Sci. 2019 Sep 20;20(19):4666. doi: 10.3390/ijms20194666.PMID: 31547084 Review.

Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy. Jiang B, Aliyan A, Cook NP, Augustine A, Bhak G, Maldonado R, Smith McWilliams AD, Flores EM, Mendez N, Shahnawaz M, Godoy FJ, Montenegro J, Moreno-Gonzalez I, Martí AA. J Am Chem Soc. 2019 Oct 2;141(39):15605-15610. doi: 10.1021/jacs.9b06966. Epub 2019 Sep 19. PMID: 31536338

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients. Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A. Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. PMID: 31491047

Traumatic Brain Injury Induces Tau Aggregation and Spreading. Edwards G 3rd, Zhao J, Dash PK, Soto C, Moreno-Gonzalez I. J Neurotrauma. 2020 Jan 1;37(1):80-92. doi: 10.1089/neu.2018.6348. Epub 2019 Aug 28. PMID: 31317824

Modifiable Risk Factors for Alzheimer’s Disease. Edwards Iii GA, Gamez N, Escobedo G Jr, Calderon O, Moreno-Gonzalez I. Front Aging Neurosci. 2019 Jun 24;11:146. doi: 10.3389/fnagi.2019.00146. eCollection 2019. PMID: 31293412

Impaired Peripheral Lymphatic Function and Cerebrospinal Fluid Outflow in a Mouse Model of Alzheimer’s Disease. Kwon S, Moreno-Gonzalez I, Taylor-Presse K, Edwards Iii G, Gamez N, Calderon O, Zhu B, Velasquez FC, Soto C, Sevick-Muraca EM. J Alzheimers Dis. 2019;69(2):585-593. doi: 10.3233/JAD-190013. PMID: 31104026

Soft-Lithographic Patterning of Luminescent Carbon Nanodots Derived from Collagen Waste. Meiyazhagan A, Aliyan A, Ayyappan A, Moreno-Gonzalez I, Susarla S, Yazdi S, Cuanalo-Contreras K, Khabashesku VN, Vajtai R, Martí AA, Ajayan PM. ACS Appl Mater Interfaces. 2018 Oct 24;10(42):36275-36283. doi: 10.1021/acsami.8b13114. Epub 2018 Oct 15. PMID: 30270613

Inhibition of protein misfolding and aggregation by natural phenolic compounds. Dhouafli Z, Cuanalo-Contreras K, Hayouni EA, Mays CE, Soto C, Moreno-Gonzalez I. Cell Mol Life Sci. 2018 Oct;75(19):3521-3538. doi: 10.1007/s00018-018-2872-2. Epub 2018 Jul 20. PMID: 30030591 Review.

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. Mukherjee A, Morales-Scheihing D, Salvadores N, Moreno-Gonzalez I, Gonzalez C, Taylor-Presse K, Mendez N, Shahnawaz M, Gaber AO, Sabek OM, Fraga DW, Soto C. J Exp Med. 2017 Sep 4;214(9):2591-2610. doi: 10.1084/jem.20161134. Epub 2017 Aug 1. PMID: 28765400

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice. Carlock C, Wu J, Shim J, Moreno-Gonzalez I, Pitcher MR, Hicks J, Suzuki A, Iwata J, Quevado J, Lou Y. Transl Psychiatry. 2017 Jul 4;7(7):e1164. doi: 10.1038/tp.2017.142. PMID: 28675392

Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo. Diaz-Espinoza R, Morales R, Concha-Marambio L, Moreno-Gonzalez I, Moda F, Soto C. Mol Psychiatry. 2018 Mar;23(3):777-788. doi: 10.1038/mp.2017.84. Epub 2017 Jun 20. PMID: 28630454

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo. Park KW, Eun Kim G, Morales R, Moda F, Moreno-Gonzalez I, Concha-Marambio L, Lee AS, Hetz C, Soto C. Sci Rep. 2017 Mar 23;7:44723. doi: 10.1038/srep44723. PMID: 28333162

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding. Moreno-Gonzalez I, Edwards Iii G, Salvadores N, Shahnawaz M, Diaz-Espinoza R, Soto C. Mol Psychiatry. 2017 Sep;22(9):1327-1334. doi: 10.1038/mp.2016.230. Epub 2017 Jan 3. PMID: 28044060

Amyloid-beta and tau pathology following repetitive mild traumatic brain injury. Edwards G 3rd, Moreno-Gonzalez I, Soto C. Biochem Biophys Res Commun. 2017 Feb 19;483(4):1137-1142. doi: 10.1016/j.bbrc.2016.07.123. Epub 2016 Aug 1. PMID: 27492070 Review.

Role of Prion Replication in the Strain-dependent Brain Regional Distribution of Prions. Hu PP, Morales R, Duran-Aniotz C, Moreno-Gonzalez I, Khan U, Soto C. J Biol Chem. 2016 Jun 10;291(24):12880-7. doi: 10.1074/jbc.M115.681791. Epub 2016 Apr 7. PMID: 27056328

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. Carriba P, Jimenez S, Navarro V, Moreno-Gonzalez I, Barneda-Zahonero B, Moubarak RS, Lopez-Soriano J, Gutierrez A, Vitorica J, Comella JX. Cell Death Dis. 2015 Feb 12;6(2):e1639. doi: 10.1038/cddis.2015.6. PMID: 25675299

Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer’s disease. Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Hu PP, Fedynyshyn J, Soto C. PLoS One. 2014 Feb 12;9(2):e89014. doi: 10.1371/journal.pone.0089014. eCollection 2014. PMID: 24533166

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology. Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Acta Neuropathol Commun. 2013 Nov 12;1:73. doi: 10.1186/2051-5960-1-73. PMID: 24252759

Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo. Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Hu PP, Soto C. Acta Neuropathol Commun. 2013 Nov 18;1(1):76. doi: 10.1186/2051-5960-1-76. PMID: 24252208

Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases. Morales R, Moreno-Gonzalez I, Soto C. PLoS Pathog. 2013 Sep;9(9):e1003537. doi: 10.1371/journal.ppat.1003537. Epub 2013 Sep 19. PMID: 24068917

Amyloid aggregates: role in Protein Misfolding Disorders. Duran-Aniotz C, Moreno-Gonzalez I, Morales R. Rev Med Chil. 2013 Apr;141(4):495-505. doi: 10.4067/S0034-98872013000400011. PMID: 23900371 Review

Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease. Moreno-Gonzalez I, Estrada LD, Sanchez-Mejias E, Soto C. Nat Commun. 2013;4:1495. doi: 10.1038/ncomms2494. PMID: 23422663

Natural animal models of neurodegenerative protein misfolding diseases. Moreno-Gonzalez I, Soto C. Curr Pharm Des. 2012;18(8):1148-58. doi: 10.2174/138161212799315768. PMID: 22288404 Review.

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus. Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A. Acta Neuropathol. 2012 Jan;123(1):53-70. doi: 10.1007/s00401-011-0896-x. Epub 2011 Oct 22. PMID: 22020633

Misfolded protein aggregates: mechanisms, structures and potential for disease transmission. Moreno-Gonzalez I, Soto C. Semin Cell Dev Biol. 2011 Jul;22(5):482-7. doi: 10.1016/j.semcdb.2011.04.002. Epub 2011 May 5. PMID: 21571086

Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus. Baglietto-Vargas D, Moreno-Gonzalez I, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A. J Alzheimers Dis. 2010;21(1):119-32. doi: 10.3233/JAD-2010-100066.
PMID: 20413859

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice. Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Del Rio JC, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A. J Alzheimers Dis. 2009;18(4):755-76. doi: 10.3233/JAD-2009-1192. PMID: 19661615

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer’s disease: age-dependent switch in the microglial phenotype from alternative to classic. Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J. J Neurosci. 2008 Nov 5;28(45):11650-61. doi: 10.1523/JNEUROSCI.3024-08.2008. PMID: 18987201 Free PMC article.

Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons. Gavilán MP, Revilla E, Pintado C, Castaño A, Vizuete ML, Moreno-González I, Baglietto-Vargas D, Sánchez-Varo R, Vitorica J, Gutiérrez A, Ruano D. J Neurochem. 2007 Nov;103(3):984-96. doi: 10.1111/j.1471-4159.2007.04787.x. Epub 2007 Jul 31. PMID: 17666053

Glutaminase activity is confined to the mantle of the islets of Langerhans. Montero F, Baglietto-Vargas D, Moreno-González I, López-Tellez JF, Cuesta-Munoz AL, Gutiérrez A, Aledo JC. Biochimie. 2007 Nov;89(11):1366-71. doi: 10.1016/j.biochi.2007.05.008. Epub 2007 Jun 2. PMID: 17614191

Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice. Caballero C, Jimenez S, Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Gavilan MP, Ramos B, Del Rio JC, Vizuete M, Gutierrez A, Ruano D, Vitorica J. J Neurosci Res. 2007 Mar;85(4):787-97. doi: 10.1002/jnr.21172. PMID: 17243176

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer’s disease. Ramos B, Baglietto-Vargas D, del Rio JC, Moreno-Gonzalez I, Santa-Maria C, Jimenez S, Caballero C, Lopez-Tellez JF, Khan ZU, Ruano D, Gutierrez A, Vitorica J. Neurobiol Aging. 2006 Nov;27(11):1658-72. doi: 10.1016/j.neurobiolaging.2005.09.022. Epub 2005 Nov 3. PMID: 16271420

Segregation of two glutaminase isoforms in islets of Langerhans. Baglietto-Vargas D, López-Téllez JF, Moreno-González I, Gutiérrez A, Aledo JC. Biochem J. 2004 Jul 15;381(Pt 2):483-7. doi: 10.1042/BJ20040523. PMID: 15089745 Free PMC article